Melanosomes — dark organelles enlighten endosomal membrane transport
نویسندگان
چکیده
منابع مشابه
Membrane transport: Ubiquitylation in endosomal sorting
In yeast, membrane proteins from the biosynthetic and endocytic pathways must be ubiquitylated for sorting to inward-budding vesicles in late endosomes, which give rise to multivesicular bodies. A conserved protein complex containing the yeast Vps23p or its mammalian counterpart Tsg101 may act as the ubiquitin receptor.
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Hermansky-Pudlak syndrome (HPS) is a group of disorders characterized by the malformation of lysosome-related organelles, such as pigment cell melanosomes. Three of nine characterized HPS subtypes result from mutations in subunits of BLOC-2, a protein complex with no known molecular function. In this paper, we exploit melanocytes from mouse HPS models to place BLOC-2 within a cargo transport pa...
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Those of us experiencing graying hair may be more sensitive to the term melanosome than other readers. You will find no remedy within this article, but rather a jealous look at the organisms which are able to manipulate their skin color, for example to match the appearance of their environment. In fish and amphibians, this change is brought about by movements of pigment-containing vesicles, mel...
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2007
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm2258